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Document type:
journal article 
Author(s):
del Pilar Martin, M; Cravens, PD; Winger, R; Frohman, EM; Racke, MK; Eagar, TN; Zamvil, SS; Weber, MS; Hemmer, B; Karandikar, NJ; Kleinschmidt-DeMasters, BK; Stüve, O 
Title:
Decrease in the numbers of dendritic cells and CD4+ T cells in cerebral perivascular spaces due to natalizumab. 
Abstract:
OBJECTIVE: To extend our studies on the prolonged and differential effect of natalizumab on T lymphocyte numbers in the cerebrospinal fluid, we investigated the number and phenotypes of leukocytes and the expression of major histocompatibility complex (MHC) classes I and II in cerebral perivascular spaces (CPVS). We hypothesized that natalizumab reduces the number of antigen presenting cells in CPVS. DESIGN: A case-control study in which inflammatory cell numbers in the CPVS of cerebral tissue w...    »
 
Journal title abbreviation:
Arch Neurol 
Year:
2008 
Journal volume:
65 
Journal issue:
12 
Pages contribution:
1596-603 
Language:
eng 
Print-ISSN:
0003-9942 
TUM Institution:
Neurologische Klinik und Poliklinik