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- Document type:
- Journal Article; Research Support, Non-U.S. Gov't; Article
- Author(s):
- Sellner, J; Greeve, I; Mattle, HP
- Title:
- Atorvastatin decreases high-sensitivity C-reactive protein in multiple sclerosis.
- Abstract:
- The anti-inflammatory potential of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, as reflected by modulation of C-reactive protein (CRP), might be beneficial in the treatment of patients with multiple sclerosis (MS). We evaluated serum levels of high-sensitivity (hs)-CRP in relapsing-remitting MS patients receiving interferon-beta 1b and atorvastatin as add-on therapy. This study shows that interferon-beta treatment is associated with increased serum levels of hs-CRP in MS patients (P<0.01). In contrast, when atorvastatin is added to interferon-beta, hs-CRP serum levels decrease to the normal range (P<0.05), indicating an anti-inflammatory action of atorvastatin in MS. However, whether add-on treatment with atorvastatin modifies the course of MS remains to be investigated.
- Journal title abbreviation:
- Mult Scler
- Year:
- 2008
- Journal volume:
- 14
- Journal issue:
- 7
- Pages contribution:
- 981-4
- Language:
- eng
- Fulltext / DOI:
- doi:10.1177/1352458508091368
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/18573823
- Print-ISSN:
- 1352-4585
- TUM Institution:
- Neurologische Klinik und Poliklinik
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