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Document type:
journal article 
Author(s):
Sellner, J; Greeve, I; Mattle, HP 
Title:
Atorvastatin decreases high-sensitivity C-reactive protein in multiple sclerosis. 
Abstract:
The anti-inflammatory potential of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, as reflected by modulation of C-reactive protein (CRP), might be beneficial in the treatment of patients with multiple sclerosis (MS). We evaluated serum levels of high-sensitivity (hs)-CRP in relapsing-remitting MS patients receiving interferon-beta 1b and atorvastatin as add-on therapy. This study shows that interferon-beta treatment is associated with increased serum levels of hs-CRP in MS patients (P<0.01). In contrast, when atorvastatin is added to interferon-beta, hs-CRP serum levels decrease to the normal range (P<0.05), indicating an anti-inflammatory action of atorvastatin in MS. However, whether add-on treatment with atorvastatin modifies the course of MS remains to be investigated. 
Journal title abbreviation:
Mult Scler 
Year:
2008 
Journal volume:
14 
Journal issue:
Pages contribution:
981-4 
Language:
eng 
Print-ISSN:
1352-4585 
TUM Institution:
Neurologische Klinik und Poliklinik