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Document type:
journal article 
Author(s):
Xiao, S; Jin, H; Korn, T; Liu, SM; Oukka, M; Lim, B; Kuchroo, VK 
Title:
Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression. 
Abstract:
The de novo generation of Foxp3+ regulatory T (Treg) cells in the peripheral immune compartment and the differentiation of Th17 cells both require TGF-beta, and IL-6 and IL-21 are switch factors that drive the development of Th17 cells at the expense of Treg cell generation. The major vitamin A metabolite all-trans retinoic acid (RA) not only enforces the generation of Treg cells but also inhibits the differentiation of Th17 cells. Herein we show that RA enhances TGF-beta signaling by increasing...    »
 
Journal title abbreviation:
J Immunol 
Year:
2008 
Journal volume:
181 
Journal issue:
Pages contribution:
2277-84 
Language:
eng 
Print-ISSN:
0022-1767 
TUM Institution:
Neurologische Klinik und Poliklinik