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Dokumenttyp:
journal article 
Autor(en):
Xiao, S; Jin, H; Korn, T; Liu, SM; Oukka, M; Lim, B; Kuchroo, VK 
Titel:
Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression. 
Abstract:
The de novo generation of Foxp3+ regulatory T (Treg) cells in the peripheral immune compartment and the differentiation of Th17 cells both require TGF-beta, and IL-6 and IL-21 are switch factors that drive the development of Th17 cells at the expense of Treg cell generation. The major vitamin A metabolite all-trans retinoic acid (RA) not only enforces the generation of Treg cells but also inhibits the differentiation of Th17 cells. Herein we show that RA enhances TGF-beta signaling by increasing...    »
 
Zeitschriftentitel:
J Immunol 
Jahr:
2008 
Band / Volume:
181 
Heft / Issue:
Seitenangaben Beitrag:
2277-84 
Sprache:
eng 
Print-ISSN:
0022-1767 
TUM Einrichtung:
Neurologische Klinik und Poliklinik