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Document type:
journal article 
Author(s):
Mueck, W; Borris, LC; Dahl, OE; Haas, S; Huisman, MV; Kakkar, AK; Kälebo, P; Muelhofer, E; Misselwitz, F; Eriksson, BI 
Title:
Population pharmacokinetics and pharmacodynamics of once- and twice-daily rivaroxaban for the prevention of venous thromboembolism in patients undergoing total hip replacement. 
Abstract:
Rivaroxaban (Xarelto) is an oral, direct factor Xa inhibitor in advanced clinical development for the prevention and treatment of thromboembolic disorders. The aim was to compare the population pharmacokinetics (PK) and pharmacodynamics (PD) of twice-daily (bid) and once-daily (od) rivaroxaban in patients undergoing total hip replacement (THR). Blood samples were collected from patients enrolled in two phase IIb, dose-ranging studies undertaken to investigate rivaroxaban for thromboprophylaxis a...    »
 
Journal title abbreviation:
Thromb Haemost 
Year:
2008 
Journal volume:
100 
Journal issue:
Pages contribution:
453-61 
Language:
eng 
Print-ISSN:
0340-6245 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung