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Dokumenttyp:
journal article 
Autor(en):
Mueck, W; Eriksson, BI; Bauer, KA; Borris, L; Dahl, OE; Fisher, WD; Gent, M; Haas, S; Huisman, MV; Kakkar, AK; Kälebo, P; Kwong, LM; Misselwitz, F; Turpie, AG 
Titel:
Population pharmacokinetics and pharmacodynamics of rivaroxaban--an oral, direct factor Xa inhibitor--in patients undergoing major orthopaedic surgery. 
Abstract:
BACKGROUND: There is a clinical need for novel oral anticoagulants with predictable pharmacokinetics and pharmacodynamics. Rivaroxaban is an oral direct Factor Xa (FXa) inhibitor in clinical development for the prevention and treatment of thromboembolic disorders. This analysis was performed to characterize the population pharmacokinetics and pharmacodynamics of rivaroxaban in patients participating in two phase II, double-blind, randomized, active-comparator-controlled studies of twice-daily ri...    »
 
Zeitschriftentitel:
Clin Pharmacokinet 
Jahr:
2008 
Band / Volume:
47 
Heft / Issue:
Seitenangaben Beitrag:
203-16 
Sprache:
eng 
Print-ISSN:
0312-5963 
TUM Einrichtung:
r experimentelle Onkologie und Therapieforschung