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Document type:
journal article 
Author(s):
Mueck, W; Eriksson, BI; Bauer, KA; Borris, L; Dahl, OE; Fisher, WD; Gent, M; Haas, S; Huisman, MV; Kakkar, AK; Kälebo, P; Kwong, LM; Misselwitz, F; Turpie, AG 
Title:
Population pharmacokinetics and pharmacodynamics of rivaroxaban--an oral, direct factor Xa inhibitor--in patients undergoing major orthopaedic surgery. 
Abstract:
BACKGROUND: There is a clinical need for novel oral anticoagulants with predictable pharmacokinetics and pharmacodynamics. Rivaroxaban is an oral direct Factor Xa (FXa) inhibitor in clinical development for the prevention and treatment of thromboembolic disorders. This analysis was performed to characterize the population pharmacokinetics and pharmacodynamics of rivaroxaban in patients participating in two phase II, double-blind, randomized, active-comparator-controlled studies of twice-daily ri...    »
 
Journal title abbreviation:
Clin Pharmacokinet 
Year:
2008 
Journal volume:
47 
Journal issue:
Pages contribution:
203-16 
Language:
eng 
Print-ISSN:
0312-5963 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung