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Dokumenttyp:
journal article 
Autor(en):
Schillinger, U; Wexel, G; Hacker, C; Kullmer, M; Koch, C; Gerg, M; Vogt, S; Ueblacker, P; Tischer, T; Hensler, D; Wilisch, J; Aigner, J; Walch, A; Stemberger, A; Plank, C 
Titel:
A fibrin glue composition as carrier for nucleic acid vectors. 
Abstract:
PURPOSE: Gene delivery from biomaterials has become an important tool in tissue engineering. The purpose of this study was to generate a gene vector-doted fibrin glue as a versatile injectable implant to be used in gene therapy supported tissue regeneration. METHODS: Copolymer-protected polyethylenimine(PEI)-DNA vectors (COPROGs), naked DNA and PEI-DNA were formulated with the fibrinogen component of the fibrin glue TISSUCOL and lyophilized. Clotting parameters upon rehydration and thrombin addi...    »
 
Zeitschriftentitel:
Pharm Res 
Jahr:
2008 
Band / Volume:
25 
Heft / Issue:
12 
Seitenangaben Beitrag:
2946-62 
Sprache:
eng 
Print-ISSN:
0724-8741 
TUM Einrichtung:
r experimentelle Onkologie und Therapieforschung; dische Klinik und Poliklinik