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Document type:
journal article 
Author(s):
Lutz, J; Luong, LA; Strobl, M; Deng, M; Huang, H; Anton, M; Zakkar, M; Enesa, K; Chaudhury, H; Haskard, DO; Baumann, M; Boyle, J; Harten, S; Maxwell, PH; Pusey, C; Heemann, U; Evans, PC 
Title:
The A20 gene protects kidneys from ischaemia/reperfusion injury by suppressing pro-inflammatory activation. 
Abstract:
Ischaemia followed by reperfusion (I/R) can induce inflammation and injury and is a risk factor for delayed graft function and rejection of transplanted kidneys. Inflammation is regulated by NF-kappaB transcription factors which induce pro-inflammatory molecules in endothelial cells (EC). We examined whether A20, a negative regulator of NF-kappaB, can protect kidneys from I/R injury. To mimic the fluctuations in endothelial oxygenation that occur during I/R we exposed cultured human umbilical ve...    »
 
Journal title abbreviation:
J Mol Med 
Year:
2008 
Journal volume:
86 
Journal issue:
12 
Pages contribution:
1329-39 
Language:
eng 
Print-ISSN:
0946-2716 
TUM Institution:
r Nephrologie; r experimentelle Onkologie und Therapieforschung 
Format:
Text