User: Guest  Login
Document type:
journal article 
Author(s):
Von Hahn, T; Halangk, J; Witt, H; Neumann, K; Müller, T; Puhl, G; Neuhaus, P; Nickel, R; Beuers, U; Wiedenmann, B; Berg, T 
Title:
Relevance of endotoxin receptor CD14 and TLR4 gene variants in chronic liver disease. 
Abstract:
OBJECTIVE: The lipopolysaccharide (LPS)-triggered release of inflammatory cytokines from Kupffer cells is mediated via the CD14/TLR4 receptor complex. This inflammatory pathway can be influenced by alterations in genes encoding for LPS receptor components. Thus, a -260 C>T transition in the CD14 promoter is thought to result in enhanced CD14 expression thereby increasing the LPS responsiveness in chronic liver diseases, whereas a D299G exchange in the TLR4 gene has the opposite effect. Our objec...    »
 
Journal title abbreviation:
Scand J Gastroenterol 
Year:
2008 
Journal volume:
43 
Journal issue:
Pages contribution:
584-92 
Language:
eng 
Print-ISSN:
0036-5521 
TUM Institution:
hrungsmedizin