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Dokumenttyp:
journal article 
Autor(en):
Von Hahn, T; Halangk, J; Witt, H; Neumann, K; Müller, T; Puhl, G; Neuhaus, P; Nickel, R; Beuers, U; Wiedenmann, B; Berg, T 
Titel:
Relevance of endotoxin receptor CD14 and TLR4 gene variants in chronic liver disease. 
Abstract:
OBJECTIVE: The lipopolysaccharide (LPS)-triggered release of inflammatory cytokines from Kupffer cells is mediated via the CD14/TLR4 receptor complex. This inflammatory pathway can be influenced by alterations in genes encoding for LPS receptor components. Thus, a -260 C>T transition in the CD14 promoter is thought to result in enhanced CD14 expression thereby increasing the LPS responsiveness in chronic liver diseases, whereas a D299G exchange in the TLR4 gene has the opposite effect. Our objec...    »
 
Zeitschriftentitel:
Scand J Gastroenterol 
Jahr:
2008 
Band / Volume:
43 
Heft / Issue:
Seitenangaben Beitrag:
584-92 
Sprache:
eng 
Print-ISSN:
0036-5521 
TUM Einrichtung:
hrungsmedizin