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Dokumenttyp:
journal article 
Autor(en):
Halangk, J; Sarrazin, C; Neumann, K; Puhl, G; Mueller, T; Teuber, G; Klinker, H; Hinrichsen, H; Buggisch, P; Landt, O; Weich, V; Bergk, A; Wiedenmann, B; Neuhaus, P; Berg, T; Witt, H 
Titel:
Evaluation of complement factor 5 variants as genetic risk factors for the development of advanced fibrosis in chronic hepatitis C infection. 
Abstract:
BACKGROUND/AIMS: Intercross studies in inbred mice susceptible or resistant to liver fibrosis revealed complement factor 5 as a quantitative trait gene associated with the development of fibrosis. In 277 patients with hepatitis C, two C5 SNPs, rs17611 and rs2300929, have been associated with advanced fibrosis. METHODS: We investigated the association of these C5 SNPs with advanced fibrosis in 1435 HCV infected patients and in 1003 patients with other liver diseases. We performed genotyping with...    »
 
Zeitschriftentitel:
J Hepatol 
Jahr:
2008 
Band / Volume:
49 
Heft / Issue:
Seitenangaben Beitrag:
339-45 
Sprache:
eng 
Print-ISSN:
0168-8278 
TUM Einrichtung:
hrungsmedizin