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Dokumenttyp:
journal article 
Autor(en):
Aguib, Y; Gilch, S; Krammer, C; Ertmer, A; Groschup, MH; Schätzl, HM 
Titel:
Neuroendocrine cultured cells counteract persistent prion infection by down-regulation of PrPc. 
Abstract:
Cell models for prion diseases are mainly of neuronal origin. However, the pathological isoform PrP(Sc) of cellular prion protein (PrP(c)) and prion infectivity are found in a variety of extraneural tissues in prion diseases. Although many cell types are not able to propagate PrP(Sc), little is known about cellular mechanism counteracting prion infection. It is desirable to identify neuronal or non-neuronal cell models that restrict PrP(Sc) generation or propagate PrP(Sc) only transiently. Neuro...    »
 
Zeitschriftentitel:
Mol Cell Neurosci 
Jahr:
2008 
Band / Volume:
38 
Heft / Issue:
Seitenangaben Beitrag:
98-109 
Sprache:
eng 
Print-ISSN:
1044-7431 
TUM Einrichtung:
r Virologie