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Document type:
journal article 
Author(s):
Aguib, Y; Gilch, S; Krammer, C; Ertmer, A; Groschup, MH; Schätzl, HM 
Title:
Neuroendocrine cultured cells counteract persistent prion infection by down-regulation of PrPc. 
Abstract:
Cell models for prion diseases are mainly of neuronal origin. However, the pathological isoform PrP(Sc) of cellular prion protein (PrP(c)) and prion infectivity are found in a variety of extraneural tissues in prion diseases. Although many cell types are not able to propagate PrP(Sc), little is known about cellular mechanism counteracting prion infection. It is desirable to identify neuronal or non-neuronal cell models that restrict PrP(Sc) generation or propagate PrP(Sc) only transiently. Neuro...    »
 
Journal title abbreviation:
Mol Cell Neurosci 
Year:
2008 
Journal volume:
38 
Journal issue:
Pages contribution:
98-109 
Language:
eng 
Print-ISSN:
1044-7431 
TUM Institution:
Institut für Virologie