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Dokumenttyp:
journal article 
Autor(en):
Schlosser, E; Otero, C; Wuensch, C; Kessler, B; Edelmann, M; Brunisholz, R; Drexler, I; Legler, DF; Groettrup, M 
Titel:
A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins. 
Abstract:
Proteins bearing an endoplasmic reticulum (ER) leader are inserted into the ER followed by cleavage of the signal peptide. Major histocompatibility complex class I-restricted T-cell epitopes can be generated from these proteins by the proteasome after retrotranslocation into the cytosol. Here, we show that an HLA-A(*)0201-restricted epitope from prostate stem cell antigen contains the cleavage site of the ER signal peptidase. The resulting cleavage products fail to bind to HLA-A(*)0201 and are n...    »
 
Zeitschriftentitel:
EMBO Rep 
Jahr:
2007 
Band / Volume:
Heft / Issue:
10 
Seitenangaben Beitrag:
945-51 
Sprache:
eng 
Print-ISSN:
1469-221X 
TUM Einrichtung:
r Virologie