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Document type:
journal article 
Author(s):
Gilch, S; Nunziante, M; Ertmer, A; Schätzl, HM 
Title:
Strategies for eliminating PrP(c) as substrate for prion conversion and for enhancing PrP(Sc) degradation. 
Abstract:
Prion diseases are fatal neurodegenerative infectious disorders for which no therapeutic or prophylactic regimens exist. Our work aims to eliminate PrP(c) as substrate for the conversion into PrP(Sc) and to increase the cellular clearance capacity of PrP(Sc). In order to achieve the first objective, we used chemical compounds which interfere with the subcellular trafficking of PrP(c), e.g. by intracellular re-routing. Recently, we found that PrP(c) requires cholesterol for cell surface localisat...    »
 
Journal title abbreviation:
Vet Microbiol 
Year:
2007 
Journal volume:
123 
Journal issue:
Pages contribution:
377-86 
Language:
eng 
Print-ISSN:
0378-1135 
TUM Institution:
Institut für Virologie