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Document type:
journal article 
Author(s):
Simoneau, S; Rezaei, H; Salès, N; Kaiser-Schulz, G; Lefebvre-Roque, M; Vidal, C; Fournier, JG; Comte, J; Wopfner, F; Grosclaude, J; Schätzl, H; Lasmézas, CI 
Title:
In vitro and in vivo neurotoxicity of prion protein oligomers. 
Abstract:
The mechanisms underlying prion-linked neurodegeneration remain to be elucidated, despite several recent advances in this field. Herein, we show that soluble, low molecular weight oligomers of the full-length prion protein (PrP), which possess characteristics of PrP to PrPsc conversion intermediates such as partial protease resistance, are neurotoxic in vitro on primary cultures of neurons and in vivo after subcortical stereotaxic injection. Monomeric PrP was not toxic. Insoluble, fibrillar form...    »
 
Journal title abbreviation:
PLoS Pathog 
Year:
2007 
Journal volume:
Journal issue:
Pages contribution:
e125 
Language:
eng 
Print-ISSN:
1553-7366 
TUM Institution:
r Virologie