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Document type:
journal article 
Author(s):
Gilch, S; Schmitz, F; Aguib, Y; Kehler, C; Bülow, S; Bauer, S; Kremmer, E; Schätzl, HM 
Title:
CpG and LPS can interfere negatively with prion clearance in macrophage and microglial cells. 
Abstract:
Cells of the innate immune system play important roles in the progression of prion disease after peripheral infection. It has been found in vivo and in vitro that the expression of the cellular prion protein (PrP(c)) is up-regulated on stimulation of immune cells, also indicating the functional importance of PrP(c) in the immune system. The aim of our study was to investigate the impact of cytosine-phosphate-guanosine- and lipopolysaccharide-induced PrP(c) up-regulation on the uptake and process...    »
 
Journal title abbreviation:
FEBS J 
Year:
2007 
Journal volume:
274 
Journal issue:
22 
Pages contribution:
5834-44 
Language:
eng 
Print-ISSN:
1742-464X 
TUM Institution:
Institut für Virologie