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Document type:
journal article 
Author(s):
Oboznaya, MB; Gilch, S; Titova, MA; Koroev, DO; Volkova, TD; Volpina, OM; Schätzl, HM 
Title:
Antibodies to a nonconjugated prion protein peptide 95-123 interfere with PrP( Sc ) propagation in prion-infected cells. 
Abstract:
1. Vaccination-induced anti-prion protein antibodies are presently regarded as a promising approach toward treatment of prion diseases. Here, we investigated the ability of five peptides corresponding to three different regions of the bovine prion protein (PrP) to elicit antibodies interfering with PrP(Sc) propagation in prion-infected cells.2. Rabbits were immunized with free nonconjugated peptides. Obtained immune sera were tested in enzyme-linked immunosorbent assay (ELISA) and immunoblot for...    »
 
Journal title abbreviation:
Cell Mol Neurobiol 
Year:
2007 
Journal volume:
27 
Journal issue:
Pages contribution:
271-84 
Language:
eng 
Print-ISSN:
0272-4340 
TUM Institution:
Institut für Virologie