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Document type:
journal article 
Author(s):
Gross, C; Holler, E; Stangl, S; Dickinson, A; Pockley, AG; Asea, AA; Mallappa, N; Multhoff, G 
Title:
An Hsp70 peptide initiates NK cell killing of leukemic blasts after stem cell transplantation. 
Abstract:
In contrast to solid tumors, leukemic blasts frequently present both Hsp70 and HLA-E on their cell surface and thereby present activating and inhibitory signals to CD94(+) NK cells. In the first 12 months after stem cell transplantation (SCT) CD94(+) NK cells clearly dominate over CD3(+)/CD16(-)/56(-) T and CD3(+)/CD16(+)/56(+) NK-like T cells. An incubation of post-SCT-derived peripheral blood lymphocytes with the Hsp70 peptide TKD and IL-15 enhances the cell surface density of CD56/CD94 and in...    »
 
Journal title abbreviation:
Leuk Res 
Year:
2008 
Journal volume:
32 
Journal issue:
Pages contribution:
527-34 
Language:
eng 
Print-ISSN:
0145-2126 
TUM Institution:
Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie