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Document type:
journal article 
Author(s):
Dittmann, KH; Mayer, C; Ohneseit, PA; Raju, U; Andratschke, NH; Milas, L; Rodemann, HP 
Title:
Celecoxib induced tumor cell radiosensitization by inhibiting radiation induced nuclear EGFR transport and DNA-repair: a COX-2 independent mechanism. 
Abstract:
PURPOSE: The purpose of the study was to elucidate the molecular mechanisms mediating radiosensitization of human tumor cells by the selective cyclooxygenase (COX)-2 inhibitor celecoxib. METHODS AND MATERIALS: Experiments were performed using bronchial carcinoma cells A549, transformed fibroblasts HH4dd, the FaDu head-and-neck tumor cells, the colon carcinoma cells HCT116, and normal fibroblasts HSF7. Effects of celecoxib treatment were assessed by clonogenic cell survival, Western analysis, and...    »
 
Journal title abbreviation:
Int J Radiat Oncol Biol Phys 
Year:
2008 
Journal volume:
70 
Journal issue:
Pages contribution:
203-12 
Language:
eng 
Print-ISSN:
0360-3016 
TUM Institution:
Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie