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Dokumenttyp:
journal article 
Autor(en):
Eke, I; Sandfort, V; Storch, K; Baumann, M; Röper, B; Cordes, N 
Titel:
Pharmacological inhibition of EGFR tyrosine kinase affects ILK-mediated cellular radiosensitization in vitro. 
Abstract:
Purpose: Integrin-linked kinase (ILK) mediates signals from beta integrins and links integrins to epidermal growth factor receptor (EGFR). Previous studies have identified an antisurvival effect of ILK in irradiated cells. The aim of this study was to evaluate the role of EGFR tyrosine kinase (tk) activity for ILK-mediated radiosensitization. Materials and methods: Human FaDu squamous cell carcinoma (SCC) cells stably transfected with hyperactive ILK (ILK-hk) and ILK(fl/fl) and ILK(-/-) mouse fi...    »
 
Zeitschriftentitel:
Int J Radiat Biol 
Jahr:
2007 
Band / Volume:
83 
Heft / Issue:
11 
Seitenangaben Beitrag:
793-802 
Sprache:
eng 
Print-ISSN:
0955-3002 
TUM Einrichtung:
r Strahlentherapie und Radiologische Onkologie