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Document type:
journal article 
Author(s):
Eke, I; Sandfort, V; Storch, K; Baumann, M; Röper, B; Cordes, N 
Title:
Pharmacological inhibition of EGFR tyrosine kinase affects ILK-mediated cellular radiosensitization in vitro. 
Abstract:
Purpose: Integrin-linked kinase (ILK) mediates signals from beta integrins and links integrins to epidermal growth factor receptor (EGFR). Previous studies have identified an antisurvival effect of ILK in irradiated cells. The aim of this study was to evaluate the role of EGFR tyrosine kinase (tk) activity for ILK-mediated radiosensitization. Materials and methods: Human FaDu squamous cell carcinoma (SCC) cells stably transfected with hyperactive ILK (ILK-hk) and ILK(fl/fl) and ILK(-/-) mouse fi...    »
 
Journal title abbreviation:
Int J Radiat Biol 
Year:
2007 
Journal volume:
83 
Journal issue:
11 
Pages contribution:
793-802 
Language:
eng 
Print-ISSN:
0955-3002 
TUM Institution:
Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie