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Document type:
journal article 
Author(s):
Wiedenmann, N; Koto, M; Raju, U; Milas, L; Mason, KA 
Title:
Modulation of tumor radiation response with G3139, a bcl-2 antisense oligonucleotide. 
Abstract:
Overexpression of anti-apoptotic bcl-2 protein has been found in hematological and solid tumors and has been associated with increased resistance against cytotoxic therapy. While bcl-2 antisense (AS) treatment combined with chemotherapy has been successfully tested in clinical trials, trials evaluating the combination of bcl-2 AS with radiotherapy have not yet been performed. The aim of this study was to investigate in vivo anti-tumor effects of a combined modality treatment scheme consisting of...    »
 
Journal title abbreviation:
Invest New Drugs 
Year:
2007 
Journal volume:
25 
Journal issue:
Pages contribution:
411-6 
Language:
eng 
Print-ISSN:
0167-6997 
TUM Institution:
Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie