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Dokumenttyp:
journal article 
Autor(en):
Leucht, S; Shamsi, SA; Busch, R; Kissling, W; Kane, JM 
Titel:
Predicting antipsychotic drug response - replication and extension to six weeks in an international olanzapine study. 
Abstract:
OBJECTIVE: To use the degree of response after 2 weeks of treatment to predict non-response at 4 to 6 weeks. METHOD: Post-hoc re-analysis of a large multi-centered double-blind trial including 1996 patients with schizophrenia using receiver-operator curves and logistic regression analyses to predict non-response at 4 weeks and at 4-6 weeks from the percentage BPRS change at weeks 1 and 2. The primary non-response criterion was a less than 25% BPRS reduction from baseline. RESULTS: A 0% BPRS reduction at 2 weeks predicted non-response at 4 weeks with a positive predictive value of 77.1%; and sustained non-response at weeks 4, 5 and 6 with a positive predictive value of 75.8%. In a secondary last-observation-carried forward-analysis a less stringent cutoff of< or =15% BPRS reduction was associated with an acceptable positive predictive value (75%), with even higher sensitivity (76%). CONCLUSIONS: Those patients who showed little to no reduction of symptoms at week 2 were unlikely to show even minimal response at weeks 4 to 6. There is increasing evidence that such patients may benefit from a change in treatment. 
Zeitschriftentitel:
Schizophr Res 
Jahr:
2008 
Band / Volume:
101 
Heft / Issue:
1-3 
Seitenangaben Beitrag:
312-9 
Sprache:
eng 
Print-ISSN:
0920-9964 
TUM Einrichtung:
r Psychiatrie und Psychotherapie; r Medizinische Statistik und Epidemiologie