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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't 
Autor(en):
Angstenberger, M; Wegener, JW; Pichler, BJ; Judenhofer, MS; Feil, S; Alberti, S; Feil, R; Nordheim, A 
Titel:
Severe intestinal obstruction on induced smooth muscle-specific ablation of the transcription factor SRF in adult mice. 
Abstract:
SRF (Serum Response Factor), a widely expressed transcription factor, controls expression of mitogen-responsive and muscle-specific genes, thereby regulating the contractile actin microfilament. Genetic Srf deletion studies showed SRF to be indispensable for in vivo skeletal and cardiac muscle cell development. We now investigated for the first time in vivo SRF functions in smooth muscle cells of adult mice.We conditionally deleted a floxed Srf allele (Srf(flex1)) in adult mice by inducible acti...    »
 
Zeitschriftentitel:
Gastroenterology 
Jahr:
2007 
Band / Volume:
133 
Heft / Issue:
Seitenangaben Beitrag:
1948-59 
Sprache:
eng 
Print-ISSN:
0016-5085 
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie