User: Guest  Login
Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Angstenberger, M; Wegener, JW; Pichler, BJ; Judenhofer, MS; Feil, S; Alberti, S; Feil, R; Nordheim, A 
Title:
Severe intestinal obstruction on induced smooth muscle-specific ablation of the transcription factor SRF in adult mice. 
Abstract:
SRF (Serum Response Factor), a widely expressed transcription factor, controls expression of mitogen-responsive and muscle-specific genes, thereby regulating the contractile actin microfilament. Genetic Srf deletion studies showed SRF to be indispensable for in vivo skeletal and cardiac muscle cell development. We now investigated for the first time in vivo SRF functions in smooth muscle cells of adult mice.We conditionally deleted a floxed Srf allele (Srf(flex1)) in adult mice by inducible acti...    »
 
Journal title abbreviation:
Gastroenterology 
Year:
2007 
Journal volume:
133 
Journal issue:
Pages contribution:
1948-59 
Language:
eng 
Print-ISSN:
0016-5085 
TUM Institution:
Institut für Pharmakologie und Toxikologie