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Document type:
journal article 
Author(s):
Essin, K; Welling, A; Hofmann, F; Luft, FC; Gollasch, M; Moosmang, S 
Title:
Indirect coupling between Cav1.2 channels and ryanodine receptors to generate Ca2+ sparks in murine arterial smooth muscle cells. 
Abstract:
In arterial vascular smooth muscle cells (VSMCs), Ca(2+) sparks stimulate nearby Ca(2+)-activated K(+) (BK) channels that hyperpolarize the membrane and close L-type Ca(2+) channels. We tested the contribution of L-type Ca(v)1.2 channels to Ca(2+) spark regulation in tibial and cerebral artery VSMCs using VSMC-specific Ca(v)1.2 channel gene disruption in (SMAKO) mice and an approach based on Poisson statistical analysis of activation frequency and first latency of elementary events. Ca(v)1.2 cha...    »
 
Journal title abbreviation:
J Physiol 
Year:
2007 
Journal volume:
584 
Journal issue:
Pt 1 
Pages contribution:
205-19 
Language:
eng 
Print-ISSN:
0022-3751 
TUM Institution:
Institut für Pharmakologie und Toxikologie