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Document type:
journal article 
Author(s):
Herrmann, S; Stieber, J; Stöckl, G; Hofmann, F; Ludwig, A 
Title:
HCN4 provides a'depolarization reserve' and is not required for heart rate acceleration in mice. 
Abstract:
Cardiac pacemaking involves a variety of ion channels, but their relative importance is controversial and remains to be determined. Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels, which underlie the I(f) current of sinoatrial cells, are thought to be key players in cardiac automaticity. In addition, the increase in heart rate following beta-adrenergic stimulation has been attributed to the cAMP-mediated enhancement of HCN channel activity. We have now studied mice in which t...    »
 
Journal title abbreviation:
EMBO J 
Year:
2007 
Journal volume:
26 
Journal issue:
21 
Pages contribution:
4423-32 
Language:
eng 
Print-ISSN:
0261-4189 
TUM Institution:
r Pharmakologie und Toxikologie