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Document type:
journal article 
Author(s):
Weber, S; Bernhard, D; Lukowski, R; Weinmeister, P; Wörner, R; Wegener, JW; Valtcheva, N; Feil, S; Schlossmann, J; Hofmann, F; Feil, R 
Title:
Rescue of cGMP kinase I knockout mice by smooth muscle specific expression of either isozyme. 
Abstract:
Smooth muscle expresses the Ialpha and the Ibeta isoforms of cGMP-dependent protein kinase I (cGKI). Inactivation of the murine cGKI gene prkg1 leads to multiple phenotypes and premature death at approximately 6 weeks. We reconstituted mice with the cGKIalpha or -Ibeta isozyme to test which isozyme was needed to support basic smooth muscle functions. Mice were generated by gene targeting. The cGKIalpha or the -Ibeta coding sequences were placed under the control of the SM22alpha promoter to expr...    »
 
Journal title abbreviation:
Circ Res 
Year:
2007 
Journal volume:
101 
Journal issue:
11 
Pages contribution:
1096-103 
Language:
eng 
Print-ISSN:
0009-7330 
TUM Institution:
Institut für Pharmakologie und Toxikologie