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Document type:
journal article 
Author(s):
Döring, B; Pfitzer, G; Adam, B; Liebregts, T; Eckardt, D; Holtmann, G; Hofmann, F; Feil, S; Feil, R; Willecke, K 
Title:
Ablation of connexin43 in smooth muscle cells of the mouse intestine: functional insights into physiology and morphology. 
Abstract:
Connexin43 (Cx43) gap-junction channels are highly abundant in intestinal smooth muscle but their functional impact has not been studied so far. Here, we have aimed to elucidate the functional role of Cx43 in the tunica muscularis of the mouse intestine in vivo. Transgenic mice with conditional deletion of Cx43 in smooth muscle cells (SMC) were generated. Histological investigations by immunofluorescence analyses and organ-bath recordings to assess the contractility of intestinal tissue strips w...    »
 
Journal title abbreviation:
Cell Tissue Res 
Year:
2007 
Journal volume:
327 
Journal issue:
Pages contribution:
333-42 
Language:
eng 
Print-ISSN:
0302-766X 
TUM Institution:
Institut für Pharmakologie und Toxikologie