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Document type:
journal article 
Author(s):
Wörner, R; Lukowski, R; Hofmann, F; Wegener, JW 
Title:
cGMP signals mainly through cAMP kinase in permeabilized murine aorta. 
Abstract:
GMP affects vascular tone by multiple mechanisms, including inhibition of the Rho/Rho kinase-mediated Ca(2+) sensitization, a process identified as Ca(2+) desensitization. Ca(2+) desensitization is mediated probably by both cGMP- and cAMP-dependent protein kinases (cGKI and PKA). We investigate to which extent Ca(2+) desensitization is initiated by cGKI and PKA. cGMP/cAMP-induced relaxation was studied at constant [Ca(2+)] in permeabilized aortas from wild-type and cGKI-deficient mice. [Ca(2+)]...    »
 
Journal title abbreviation:
Am J Physiol Heart Circ Physiol 
Year:
2007 
Journal volume:
292 
Journal issue:
Pages contribution:
H237-44 
Language:
eng 
Print-ISSN:
0363-6135 
TUM Institution:
Institut für Pharmakologie und Toxikologie