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Dokumenttyp:
journal article 
Autor(en):
Sausbier, M; Zhou, XB; Beier, C; Sausbier, U; Wolpers, D; Maget, S; Martin, C; Dietrich, A; Ressmeyer, AR; Renz, H; Schlossmann, J; Hofmann, F; Neuhuber, W; Gudermann, T; Uhlig, S; Korth, M; Ruth, P 
Titel:
Reduced rather than enhanced cholinergic airway constriction in mice with ablation of the large conductance Ca2+-activated K+ channel. 
Abstract:
The unique voltage- and Ca2+-dependent K+ (BK) channel, prominently expressed in airway smooth muscle cells, has been suggested as an important effector in controlling airway contractility. Its deletion in mice depolarized resting membrane potential of tracheal cells, suggesting an increased open-probability of voltage-gated Ca2+ channels. While carbachol concentration-dependently increased the tonic tension of wild-type (WT) trachea, mutant trachea showed a different response with rapid tension...    »
 
Zeitschriftentitel:
FASEB J 
Jahr:
2007 
Band / Volume:
21 
Heft / Issue:
Seitenangaben Beitrag:
812-22 
Sprache:
eng 
Print-ISSN:
0892-6638 
TUM Einrichtung:
r Pharmakologie und Toxikologie