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Document type:
journal article 
Author(s):
Sausbier, M; Zhou, XB; Beier, C; Sausbier, U; Wolpers, D; Maget, S; Martin, C; Dietrich, A; Ressmeyer, AR; Renz, H; Schlossmann, J; Hofmann, F; Neuhuber, W; Gudermann, T; Uhlig, S; Korth, M; Ruth, P 
Title:
Reduced rather than enhanced cholinergic airway constriction in mice with ablation of the large conductance Ca2+-activated K+ channel. 
Abstract:
The unique voltage- and Ca2+-dependent K+ (BK) channel, prominently expressed in airway smooth muscle cells, has been suggested as an important effector in controlling airway contractility. Its deletion in mice depolarized resting membrane potential of tracheal cells, suggesting an increased open-probability of voltage-gated Ca2+ channels. While carbachol concentration-dependently increased the tonic tension of wild-type (WT) trachea, mutant trachea showed a different response with rapid tension...    »
 
Journal title abbreviation:
FASEB J 
Year:
2007 
Journal volume:
21 
Journal issue:
Pages contribution:
812-22 
Language:
eng 
Print-ISSN:
0892-6638 
TUM Institution:
Institut für Pharmakologie und Toxikologie