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Document type:
journal article 
Author(s):
Harbeck, N; Nimmrich, I; Hartmann, A; Ross, JS; Cufer, T; Grützmann, R; Kristiansen, G; Paradiso, A; Hartmann, O; Margossian, A; Martens, J; Schwope, I; Lukas, A; Müller, V; Milde-Langosch, K; Nährig, J; Foekens, J; Maier, S; Schmitt, M; Lesche, R 
Title:
Multicenter study using paraffin-embedded tumor tissue testing PITX2 DNA methylation as a marker for outcome prediction in tamoxifen-treated, node-negative breast cancer patients. 
Abstract:
PURPOSE: We recently reported DNA methylation of the paired-like homeodomain transcription factor 2 (PITX2) gene to be strongly correlated with increased risk of recurrence in node-negative, hormone receptor-positive, tamoxifen-treated breast cancer patients using fresh frozen specimens. Aims of the present study were to establish determination of PITX2 methylation for routine analysis in formalin-fixed paraffin-embedded (FFPE) breast cancer tissue and to test PITX2 DNA methylation as a biomarke...    »
 
Journal title abbreviation:
J Clin Oncol 
Year:
2008 
Journal volume:
26 
Journal issue:
31 
Pages contribution:
5036-42 
Language:
eng 
Print-ISSN:
0732-183X 
TUM Institution:
Frauenklinik und Poliklinik; r Allgemeine Pathologie und pathologische Anatomie