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Document type:
journal article 
Author(s):
Picchio, M; Beck, R; Haubner, R; Seidl, S; Machulla, HJ; Johnson, TD; Wester, HJ; Reischl, G; Schwaiger, M; Piert, M 
Title:
Intratumoral spatial distribution of hypoxia and angiogenesis assessed by 18F-FAZA and 125I-Gluco-RGD autoradiography. 
Abstract:
The hypoxia-inducible factor-1 alpha (HIF-1 alpha) activates angiogenesis in response to cellular hypoxia, suggesting a spatial correlation between angiogenesis and tissue hypoxia. METHODS: Using digital autoradiography of coinjected 18F-labeled azomycin arabinoside (8F-FAZA) (assessing regional hypoxia) and a glycosylated RGD-containing peptide (125I-3-iodo-dTyr(4)-cyclo(-Arg-Gly-Asp-dTyr-Lys(SAA)-), or 125I-Gluco-RGD) (assessing angiogenesis via binding to alpha v beta 3 integrin receptors on...    »
 
Journal title abbreviation:
J Nucl Med 
Year:
2008 
Journal volume:
49 
Journal issue:
Pages contribution:
597-605 
Language:
eng 
Print-ISSN:
0161-5505 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik; r Allgemeine Pathologie und pathologische Anatomie