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Document type:
journal article 
Author(s):
Schulz, C; Penz, S; Hoffmann, C; Langer, H; Gillitzer, A; Schneider, S; Brandl, R; Seidl, S; Massberg, S; Pichler, B; Kremmer, E; Stellos, K; Schönberger, T; Siess, W; Gawaz, M 
Title:
Platelet GPVI binds to collagenous structures in the core region of human atheromatous plaque and is critical for atheroprogression in vivo. 
Abstract:
Platelet adhesion to the atherosclerotic vascular wall induces thrombosis and boosters vascular inflammation and atheroprogression. In the present study we studied the binding of the platelet collagen receptor glycoprotein (GP) VI to human atherosclerotic plaques (AP) and the role of GPVI-mediated platelet adhesion for atheroprogression. Soluble GPVI-Fc fusion protein bound to immobilized collagen type I, collagen type III, and predominantly to the core region of human carotid atheromatous plaqu...    »
 
Journal title abbreviation:
Basic Res Cardiol 
Year:
2008 
Journal volume:
103 
Journal issue:
Pages contribution:
356-67 
Language:
eng 
Print-ISSN:
0300-8428 
TUM Institution:
I. Medizinische Klinik und Poliklinik; chirurgie; r Allgemeine Pathologie und pathologische Anatomie