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Document type:
journal article 
Author(s):
Martinez, A; Pittaluga, S; Rudelius, M; Davies-Hill, T; Sebasigari, D; Fountaine, TJ; Hewitt, S; Jaffe, ES; Raffeld, M 
Title:
Expression of the interferon regulatory factor 8/ICSBP-1 in human reactive lymphoid tissues and B-cell lymphomas: a novel germinal center marker. 
Abstract:
To assess the role of interferon regulatory factor (IRF) 8 in B-cell development and lymphomagenesis, we studied its expression in reactive lymphoid tissues, its relationship to other B-cell transcription factors, and its expression in a series of 232 B-cell tumors and 30 cell lines representing a variety of B-cell developmental stages. We found that although IRF8 was detectable in most reactive B-cells, its expression levels differed with developmental stage. Germinal center B cells contained t...    »
 
Journal title abbreviation:
Am J Surg Pathol 
Year:
2008 
Journal volume:
32 
Journal issue:
Pages contribution:
1190-200 
Language:
eng 
Print-ISSN:
0147-5185 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie