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Document type:
journal article 
Author(s):
Kremer, M; Horn, T; Koch, I; Dechow, T; Gattenloehner, S; Pfeiffer, W; Quintanilla-Martínez, L; Fend, F 
Title:
Quantitation of the JAK2V617F mutation in microdissected bone marrow trephines: equal mutational load in myeloid lineages and rare involvement of lymphoid cells. 
Abstract:
The JAK2V617F mutation is an essential oncogenic event in Philadelphia negative chronic myeloproliferative disorders (Ph-cMPD). It is still unclear how a unique tyrosine kinase mutation can give rise to the broad clinical and morphologic spectrum of Ph-cMPD. One possible explanation could be differences in the JAK2V617F gene dosage, or different maturation stages on which myeloid lineages are affected by the mutation. The extent of lymphoid lineage involvement in JAK2V617F-positive cMPD is still...    »
 
Journal title abbreviation:
Am J Surg Pathol 
Year:
2008 
Journal volume:
32 
Journal issue:
Pages contribution:
928-35 
Language:
eng 
Print-ISSN:
0147-5185 
TUM Institution:
r Allgemeine Pathologie und pathologische Anatomie; III. Medizinische Klinik und Poliklinik