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Dokumenttyp:
journal article 
Autor(en):
Kremer, M; Horn, T; Koch, I; Dechow, T; Gattenloehner, S; Pfeiffer, W; Quintanilla-Martínez, L; Fend, F 
Titel:
Quantitation of the JAK2V617F mutation in microdissected bone marrow trephines: equal mutational load in myeloid lineages and rare involvement of lymphoid cells. 
Abstract:
The JAK2V617F mutation is an essential oncogenic event in Philadelphia negative chronic myeloproliferative disorders (Ph-cMPD). It is still unclear how a unique tyrosine kinase mutation can give rise to the broad clinical and morphologic spectrum of Ph-cMPD. One possible explanation could be differences in the JAK2V617F gene dosage, or different maturation stages on which myeloid lineages are affected by the mutation. The extent of lymphoid lineage involvement in JAK2V617F-positive cMPD is still...    »
 
Zeitschriftentitel:
Am J Surg Pathol 
Jahr:
2008 
Band / Volume:
32 
Heft / Issue:
Seitenangaben Beitrag:
928-35 
Sprache:
eng 
Print-ISSN:
0147-5185 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie; III. Medizinische Klinik und Poliklinik