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Document type:
journal article 
Author(s):
Ott, K; Lordick, F; Becker, K; Ulm, K; Siewert, J; Höfler, H; Keller, G 
Title:
Glutathione-S-transferase P1, T1 and M1 genetic polymorphisms in neoadjuvant-treated locally advanced gastric cancer: GSTM1-present genotype is associated with better prognosis in completely resected patients. 
Abstract:
OBJECTIVE: Neoadjuvant chemotherapy in gastric cancer is now standard in the Western world; however, only 30-40% of the patients respond to induction therapy. Pretherapeutic predictors of response and prognosis would be of utmost interest to individualize treatment. Glutathione-S-transferase enzymes detoxify therapeutic drugs such as platin derivates and may influence outcome of the treated patients. Therefore, glutathione-S-transferase (GST) polymorphisms were assessed as predictive markers in...    »
 
Journal title abbreviation:
Int J Colorectal Dis 
Year:
2008 
Journal volume:
23 
Journal issue:
Pages contribution:
773-82 
Language:
eng 
Print-ISSN:
0179-1958 
TUM Institution:
r Allgemeine Pathologie und pathologische Anatomie; r Medizinische Statistik und Epidemiologie