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Document type:
journal article 
Author(s):
Donath, MY; Schumann, DM; Faulenbach, M; Ellingsgaard, H; Perren, A; Ehses, JA 
Title:
Islet inflammation in type 2 diabetes: from metabolic stress to therapy. 
Abstract:
Decreases in both mass and secretory function of insulin-producing beta-cells contribute to the pathophysiology of type 2 diabetes. The histology of islets from patients with type 2 diabetes displays an inflammatory process characterized by the presence of cytokines, apoptotic cells, immune cell infiltration, amyloid deposits, and eventually fibrosis. This inflammatory process is probably the combined consequence of dyslipidemia, hyperglycemia, and increased circulating adipokines. Therefore, mo...    »
 
Journal title abbreviation:
Diabetes Care 
Year:
2008 
Journal volume:
31 Suppl 2 
Pages contribution:
S161-4 
Language:
eng 
Print-ISSN:
0149-5992 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie