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Dokumenttyp:
journal article 
Autor(en):
Hapfelmeier, S; Müller, AJ; Stecher, B; Kaiser, P; Barthel, M; Endt, K; Eberhard, M; Robbiani, R; Jacobi, CA; Heikenwalder, M; Kirschning, C; Jung, S; Stallmach, T; Kremer, M; Hardt, WD 
Titel:
Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in DeltainvG S. Typhimurium colitis. 
Abstract:
Intestinal dendritic cells (DCs) are believed to sample and present commensal bacteria to the gut-associated immune system to maintain immune homeostasis. How antigen sampling pathways handle intestinal pathogens remains elusive. We present a murine colitogenic Salmonella infection model that is highly dependent on DCs. Conditional DC depletion experiments revealed that intestinal virulence of S. Typhimurium SL1344 DeltainvG mutant lacking a functional type 3 secretion system-1 (DeltainvG)critic...    »
 
Zeitschriftentitel:
J Exp Med 
Jahr:
2008 
Band / Volume:
205 
Heft / Issue:
Seitenangaben Beitrag:
437-50 
Sprache:
eng 
Print-ISSN:
0022-1007 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene; r Allgemeine Pathologie und pathologische Anatomie