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Document type:
journal article 
Author(s):
Nührenberg, TG; Langwieser, N; Schwarz, JB; Hou, Y; Frank, P; Sorge, F; Matschurat, S; Seidl, S; Kastrati, A; Schömig, A; Clauss, MA; Zohlnhöfer, D 
Title:
EMAP-II downregulation contributes to the beneficial effects of rapamycin after vascular injury. 
Abstract:
AIMS: Neointima formation after vascular injury is strongly associated with inflammation. Rapamycin inhibits human neointima formation and reduces expression of the proinflammatory cytokine endothelial-monocyte activating peptide II (EMAP-II) in vitro. Here we investigated the interplay between EMAP-II and rapamycin after vascular injury in vivo. METHODS AND RESULTS: In a mouse model of vascular injury, mice were either not treated, given everolimus, a rapamycin derivate, or subjected to simulta...    »
 
Journal title abbreviation:
Cardiovasc Res 
Year:
2008 
Journal volume:
77 
Journal issue:
Pages contribution:
580-9 
Language:
eng 
Print-ISSN:
0008-6363 
TUM Institution:
I. Medizinische Klinik und Poliklinik; r Allgemeine Pathologie und pathologische Anatomie