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Dokumenttyp:
journal article 
Autor(en):
Mao, Z; Quintanilla-Martinez, L; Raffeld, M; Richter, M; Krugmann, J; Burek, C; Hartmann, E; Rudiger, T; Jaffe, ES; Müller-Hermelink, HK; Ott, G; Fend, F; Rosenwald, A 
Titel:
IgVH mutational status and clonality analysis of Richter's transformation: diffuse large B-cell lymphoma and Hodgkin lymphoma in association with B-cell chronic lymphocytic leukemia (B-CLL) represent 2 different pathways of disease evolution. 
Abstract:
Approximately 5% of B-cell chronic lymphocytic leukemia (B-CLL) patients develop a secondary aggressive lymphoma, usually of diffuse large B-cell type (DLBCL), termed Richter's transformation (RT). Rarely, classic Hodgkin lymphoma (HL) is observed. Published small series suggest that tumor cells in DLBCL and HL can be clonally identical to the B-CLL clone or arise as an independent, secondary lymphoma. We describe the morphology, immunophenotype, and clinical features of 34 classic RT patients w...    »
 
Zeitschriftentitel:
Am J Surg Pathol 
Jahr:
2007 
Band / Volume:
31 
Heft / Issue:
10 
Seitenangaben Beitrag:
1605-14 
Sprache:
eng 
Print-ISSN:
0147-5185 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie