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Document type:
journal article 
Author(s):
Mao, Z; Quintanilla-Martinez, L; Raffeld, M; Richter, M; Krugmann, J; Burek, C; Hartmann, E; Rudiger, T; Jaffe, ES; Müller-Hermelink, HK; Ott, G; Fend, F; Rosenwald, A 
Title:
IgVH mutational status and clonality analysis of Richter's transformation: diffuse large B-cell lymphoma and Hodgkin lymphoma in association with B-cell chronic lymphocytic leukemia (B-CLL) represent 2 different pathways of disease evolution. 
Abstract:
Approximately 5% of B-cell chronic lymphocytic leukemia (B-CLL) patients develop a secondary aggressive lymphoma, usually of diffuse large B-cell type (DLBCL), termed Richter's transformation (RT). Rarely, classic Hodgkin lymphoma (HL) is observed. Published small series suggest that tumor cells in DLBCL and HL can be clonally identical to the B-CLL clone or arise as an independent, secondary lymphoma. We describe the morphology, immunophenotype, and clinical features of 34 classic RT patients w...    »
 
Journal title abbreviation:
Am J Surg Pathol 
Year:
2007 
Journal volume:
31 
Journal issue:
10 
Pages contribution:
1605-14 
Language:
eng 
Print-ISSN:
0147-5185 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie