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Dokumenttyp:
journal article 
Autor(en):
Zhao, J; Yart, A; Frigerio, S; Perren, A; Schraml, P; Weisstanner, C; Stallmach, T; Krek, W; Moch, H 
Titel:
Sporadic human renal tumors display frequent allelic imbalances and novel mutations of the HRPT2 gene. 
Abstract:
Inactivation of the HRPT2 gene encoding parafibromin was recently linked to the familial hyperparathyroidism-jaw tumor syndrome. Patients with this syndrome carry an increased risk of parathyroid and renal tumors. To determine the relevance of HRPT2 for sporadic renal tumors, clear cell, papillary and chromophobe renal cell carcinomas as well as oncocytomas and Wilms tumors were analysed for HRPT2 gene alterations. Loss of heterozygosity (LOH) of HRPT2 was found in seven of 56 (12.5%) clear cell...    »
 
Zeitschriftentitel:
Oncogene 
Jahr:
2007 
Band / Volume:
26 
Heft / Issue:
23 
Seitenangaben Beitrag:
3440-9 
Sprache:
eng 
Print-ISSN:
0950-9232 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie