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Document type:
journal article 
Author(s):
Ehses, JA; Perren, A; Eppler, E; Ribaux, P; Pospisilik, JA; Maor-Cahn, R; Gueripel, X; Ellingsgaard, H; Schneider, MK; Biollaz, G; Fontana, A; Reinecke, M; Homo-Delarche, F; Donath, MY 
Title:
Increased number of islet-associated macrophages in type 2 diabetes. 
Abstract:
Activation of the innate immune system in obesity is a risk factor for the development of type 2 diabetes. The aim of the current study was to investigate the notion that increased numbers of macrophages exist in the islets of type 2 diabetes patients and that this may be explained by a dysregulation of islet-derived inflammatory factors. Increased islet-associated immune cells were observed in human type 2 diabetic patients, high-fat-fed C57BL/6J mice, the GK rat, and the db/db mouse. When cult...    »
 
Journal title abbreviation:
Diabetes 
Year:
2007 
Journal volume:
56 
Journal issue:
Pages contribution:
2356-70 
Language:
eng 
Print-ISSN:
0012-1797 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie