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Dokumenttyp:
journal article 
Autor(en):
Larriba, MJ; Valle, N; Pálmer, HG; Ordóñez-Morán, P; Alvarez-Díaz, S; Becker, KF; Gamallo, C; de Herreros, AG; González-Sancho, JM; Muñoz, A 
Titel:
The inhibition of Wnt/{beta}-catenin signalling by 1{alpha},25-dihydroxyvitamin D3 is abrogated by Snail1 in human colon cancer cells. 
Abstract:
The Wnt/beta-catenin signalling pathway is activated in 90% of human colon cancers by nuclear accumulation of beta-catenin protein due to its own mutation or to that of adenomatous polyposis coli. In the nucleus, beta-catenin regulates gene expression promoting cell proliferation, migration and invasiveness. 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) inhibits beta-catenin signalling by inducing its binding to vitamin D receptor (VDR) and by promoting beta-catenin nuclear export. The trans...    »
 
Zeitschriftentitel:
Endocr Relat Cancer 
Jahr:
2007 
Band / Volume:
14 
Heft / Issue:
Seitenangaben Beitrag:
141-151 
Sprache:
eng 
Print-ISSN:
1351-0088 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie