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Document type:
journal article 
Author(s):
Lehmann, R; Zuellig, RA; Kugelmeier, P; Baenninger, PB; Moritz, W; Perren, A; Clavien, PA; Weber, M; Spinas, GA 
Title:
Superiority of small islets in human islet transplantation. 
Abstract:
Many factors influence the outcome of islet transplantation. As islets in the early posttransplant setting are supplied with oxygen by diffusion only and are in a hypoxic state in the portal system, we tested whether small human islets are superior to large islets both in vitro and in vivo. We assessed insulin secretion of large and small islets and quantified cell death during hypoxic conditions simulating the intraportal transplant environment. In the clinical setting, we analyzed the influenc...    »
 
Journal title abbreviation:
Diabetes 
Year:
2007 
Journal volume:
56 
Journal issue:
Pages contribution:
594-603 
Language:
eng 
Print-ISSN:
0012-1797 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie