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Dokumenttyp:
journal article 
Autor(en):
Davalos, V; Dopeso, H; Velho, S; Ferreira, AM; Cirnes, L; Díaz-Chico, N; Bilbao, C; Ramírez, R; Rodríguez, G; Falcón, O; León, L; Niessen, RC; Keller, G; Dallenbach-Hellweg, G; Espín, E; Armengol, M; Plaja, A; Perucho, M; Imai, K; Yamamoto, H; Gebert, JF; Díaz-Chico, JC; Hofstra, RM; Woerner, SM; Seruca, R; Schwartz, S; Arango, D 
Titel:
High EPHB2 mutation rate in gastric but not endometrial tumors with microsatellite instability. 
Abstract:
The EPH/EFN family of receptor tyrosine kinases regulates cell adhesion and migration and has an important role in controlling cell positioning in the normal intestinal epithelium. Inactivation of EPHB2 has recently been shown to accelerate tumorigenesis in the colon and rectum, and we have previously demonstrated frequent frameshift mutations (41%) in an A9 coding microsatellite repeat in exon 17 of EPHB2 in colorectal tumors with microsatellite instability (MSI). In this study, we extended the...    »
 
Zeitschriftentitel:
Oncogene 
Jahr:
2007 
Band / Volume:
26 
Heft / Issue:
Seitenangaben Beitrag:
308-11 
Sprache:
eng 
Print-ISSN:
0950-9232 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie