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Document type:
journal article 
Author(s):
Schlapschy, M; Theobald, I; Mack, H; Schottelius, M; Wester, HJ; Skerra, A 
Title:
Fusion of a recombinant antibody fragment with a homo-amino-acid polymer: effects on biophysical properties and prolonged plasma half-life. 
Abstract:
Chemical conjugation of small recombinant proteins with polyethylene glycol (PEG) is an established strategy to extend their typically short circulation times to a therapeutically useful range. We have investigated the production of a genetic fusion with a glycine-rich homo-amino-acid polymer (HAP) as an alternative way to attach a solvated random chain with large hydrodynamic volume. The anti-HER2 Fab fragment 4D5 was used as a model system and fused with either 100 or 200 residue polymers of t...    »
 
Journal title abbreviation:
Protein Eng Des Sel 
Year:
2007 
Journal volume:
20 
Journal issue:
Pages contribution:
273-84 
Language:
eng 
Print-ISSN:
1741-0126 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik