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Dokumenttyp:
journal article 
Autor(en):
Knör, S; Modlinger, A; Poethko, T; Schottelius, M; Wester, HJ; Kessler, H 
Titel:
Synthesis of novel 1,4,7,10-tetraazacyclodecane-1,4,7,10-tetraacetic acid (DOTA) derivatives for chemoselective attachment to unprotected polyfunctionalized compounds. 
Abstract:
A convenient synthesis of novel bifunctional poly(amino carboxylate) chelating agents allowing chemoselective attachment to highly functionalized biomolecules is described. Based on the well known chelator 1,4,7,10-tetraazacyclodecane-1,4,7,10-tetraacetic acid (DOTA), we synthesized novel bifunctional chelating agents bearing additional functional groups by alkylating 1,4,7,10-tetraazacyclododecane (cyclen) with one equivalent of para-functionalized alkyl 2-bromophenyl-acetate and three equivale...    »
 
Zeitschriftentitel:
Chemistry 
Jahr:
2007 
Band / Volume:
13 
Heft / Issue:
21 
Seitenangaben Beitrag:
6082-90 
Sprache:
eng 
Print-ISSN:
0947-6539 
TUM Einrichtung:
Nuklearmedizinische Klinik und Poliklinik