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Document type:
journal article 
Author(s):
Simberg, D; Duza, T; Park, JH; Essler, M; Pilch, J; Zhang, L; Derfus, AM; Yang, M; Hoffman, RM; Bhatia, S; Sailor, MJ; Ruoslahti, E 
Title:
Biomimetic amplification of nanoparticle homing to tumors. 
Abstract:
Nanoparticle-based diagnostics and therapeutics hold great promise because multiple functions can be built into the particles. One such function is an ability to home to specific sites in the body. We describe here biomimetic particles that not only home to tumors, but also amplify their own homing. The system is based on a peptide that recognizes clotted plasma proteins and selectively homes to tumors, where it binds to vessel walls and tumor stroma. Iron oxide nanoparticles and liposomes coate...    »
 
Journal title abbreviation:
Proc Natl Acad Sci U S A 
Year:
2007 
Journal volume:
104 
Journal issue:
Pages contribution:
932-6 
Language:
eng 
Print-ISSN:
0027-8424 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik