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Document type:
journal article 
Author(s):
Reske, SN; Deisenhofer, S; Glatting, G; Zlatopolskiy, BD; Morgenroth, A; Vogg, AT; Buck, AK; Friesen, C 
Title:
123I-ITdU-mediated nanoirradiation of DNA efficiently induces cell kill in HL60 leukemia cells and in doxorubicin-, beta-, or gamma-radiation-resistant cell lines. 
Abstract:
Resistance to radiotherapy or chemotherapy is a common cause of treatment failure in high-risk leukemias. We evaluated whether selective nanoirradiation of DNA with Auger electrons emitted by 5-(123)I-iodo-4'-thio-2'-deoxyuridine ((123)I-ITdU) can induce cell kill and break resistance to doxorubicin, beta-, and gamma-irradiation in leukemia cells. METHODS: 4'-thio-2'-deoxyuridine was radiolabeled with (123/131)I and purified by high-performance liquid chromatography. Cellular uptake, metabolic s...    »
 
Journal title abbreviation:
J Nucl Med 
Year:
2007 
Journal volume:
48 
Journal issue:
Pages contribution:
1000-7 
Language:
eng 
Print-ISSN:
0161-5505 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik