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Document type:
journal article 
Author(s):
Beck, R; Röper, B; Carlsen, JM; Huisman, MC; Lebschi, JA; Andratschke, N; Picchio, M; Souvatzoglou, M; Machulla, HJ; Piert, M 
Title:
Pretreatment 18F-FAZA PET predicts success of hypoxia-directed radiochemotherapy using tirapazamine. 
Abstract:
We evaluated the predictive value of PET using the hypoxia tracer (18)F-fluoroazomycin arabinoside ((18)F-FAZA) for success of radiotherapy in combination with tirapazamine, a specific cytotoxin for hypoxic cells. METHODS: Imaging was performed on EMT6 tumor-bearing nude mice before allocating mice into 4 groups: radiochemotherapy (RCT: 8 fractions of 4.5 Gy within 4 d combined with tirapazamine, 14 mg/kg), radiotherapy alone (RT), chemotherapy alone (tirapazamine) (CHT), or control. Treatment s...    »
 
Journal title abbreviation:
J Nucl Med 
Year:
2007 
Journal volume:
48 
Journal issue:
Pages contribution:
973-80 
Language:
eng 
Print-ISSN:
0161-5505 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik; r Strahlentherapie und Radiologische Onkologie