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Dokumenttyp:
journal article 
Autor(en):
Sellner, J; Greeve, I; Findling, O; Kamm, CP; Minten, C; Engelhardt, B; Grandgirard, D; Leib, SL; Mattle, HP 
Titel:
Effect of interferon-beta and atorvastatin on Th1/Th2 cytokines in multiple sclerosis. 
Abstract:
Beneficial effects by both interferon-beta and statin treatment in patients with multiple sclerosis (MS) may be linked to interference with the Th1/Th2 cytokine balance. We determined patterns of Th1/Th2 cytokines (interleukin (IL)-1beta, IL-2, IL-6, IL-12p70, tumor-necrosis factor (TNF)-alpha and interferon-gamma, and IL-4, IL-5 and IL-10, respectively) in the serum of patients with relapsing-remitting MS treated with 250mug interferon-beta 1b or with interferon-beta plus 40mg atorvastatin. In treatment naïve patients with MS, a trend for lower TNF-alpha serum levels compared to controls was detected (P=0.08). Interferon-beta treatment increased TNF-alpha levels, while a trend for lowering of IL-5 serum levels was found (P=0.07). Addition of atorvastatin raised IL-12p70 serum levels (P<0.05). Mean levels of two Th2 cytokines (IL-4, IL-10) showed a non-significant increase after addition of atorvastatin. We conclude that interferon-beta and atorvastatin exert divergent action on Th1/Th2 serum cytokines levels in MS. Supplemental atorvastatin might promote a Th1-type response by raising IL-12p70. Further studies are required to support a Th2 cytokine shift by atorvastatin in patients with MS. 
Zeitschriftentitel:
Neurochem Int 
Jahr:
2008 
Band / Volume:
53 
Heft / Issue:
1-2 
Seitenangaben Beitrag:
17-21 
Sprache:
eng 
Print-ISSN:
0197-0186 
TUM Einrichtung:
Neurologische Klinik und Poliklinik